Oxycodon 40 mg

Oxycodone HCl 40mg – High-Potency Opioid for Severe Refractory Pain
(Extended-Release Formulation Only – Never for Immediate Use)

Critical Safety Alert

⚠️ ABSOLUTELY CONTRAINDICATED in opioid-naïve patients
⚠️ ALLEEN VOOR GEBRUIK in opioid-tolerant patients (≥60mg MEDD for ≥1 week)
⚠️ TAMPER-RESISTANT formulation required by FDA

Therapeutisch profiel

• Bijlage II gecontroleerde stof
• ER Mechanism: 12 uur gecontroleerde afgifte
• Bioavailability: 60-87% (higher than morphine)
• Piekeffect: 4-5 uur na de dosis

Strict Indications

✔ Cancer pain bij opioïd-aangepaste patiënten
✔ Chronische pijn with documented tolerance
✔ Palliatieve zorg cases with failed lower doses

Doseringsprotocol

• Must Confirm Tolerance:
  ≥60mg oral morphine equivalents daily for ≥1 week

• Initial Conversion:
  30mg oxycodone ER q12h = 90mg oral morphine/day

• Never Crush/Chew:
  Avoid deadly rapid release

• Nieraanpassing:
  Reduce dose by 50% if CrCl <60mL/min

Misbruikafschrikkende functies

• Hardened Matrix: Resists crushing (OxyContin OP)

• Gel Formation: Snorting prevention

• FDA-Mandated REMS: Prescriber/pharmacist certification

Black Box-waarschuwingen

🛑 ADDICTION/OVERDOSE: Hoog misbruikpotentieel
🛑 NEONATAL WITHDRAWAL: Pregnancy risks
🛑 LEVENSBEDREIGENDE ADEMHALINGSDEPRESSIE

Patient Requirements

• Opioid Treatment Agreement ondertekend
• Monthly Prescriptions (geen navullingen)
• Naloxon co-recept verplicht
• Urine drugsscreening compliance

Beschikbare formuleringen

• Brand (OxyContin): Round bi-convex tablets

• Generieke geneesmiddelen: Must include FDA-approved AD properties

• Identification:
  • “OP” on one side, “40” on reverse
  • Color varies by manufacturer